New research suggests that patients who stop using blockbuster GLP-1 drugs like semaglutide or tirzepatide can put back on reduced body mass much more quickly than those who halt conventional diet and exercise plans.
Findings released in a prominent health publication points out that while overweight people can lose about a fifth of their total mass while using the jabs, the weight comes back at an estimated rate of 0.8 kg per month upon discontinuation.
"Users purchasing these drugs need to be informed of the danger of quick weight regain when the medication is stopped," stated lead investigator Dr. Susan Jebb.
Such speed of regain means a return to pre-treatment weight within about one and a half years.
Analyzing Treatments
The research, which reviewed 37 of trials involving thousands of patients, contrasted the effects of the injectable medications with other pills.
The team emphasize that people who lose weight through dieting usually see a less rapid creep back—approximately 100 grams monthly—after stopping.
The Reason for the Rapid Rebound
Doctors believe the way of the jabs is key to understanding the heightened regain.
These medications mimic a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Long-term administration of the hormone concentrations several times higher than normal may cause the body to generate a reduced amount of its endogenous hormone, and could reduce sensitivity to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Stopping of this GLP-1 'fix' means hunger is unsuppressed, making overeating a significant risk."
A Lifelong Disease?
Health authorities suggest the jabs for individuals with weight-linked health risks, accompanied by prescribed lifestyle changes.
Professionals argue that, considering the high risk of relapse, the therapy is often ongoing.
This view is supported by pharmaceutical companies, who say that the findings "emphasize the persistent character of excess weight," akin to managing diseases like high blood pressure.
Patient Experiences
Individuals who have discontinued the medication report a sudden return of cravings.
"It felt as if a trigger flipping and I was suddenly extremely hungry," described one woman.
This difficulty is worsened if patients have not established permanent dietary or behavioural modifications during therapy.
Growing Interest
Figures indicate that a significant number of people in the UK have tried these injections in the last 12 months, with interest being substantial.
- Use is more common among women than males.
- The middle-aged demographic shows the highest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than public health services.
Ultimately, experts stress that while the jabs are potent agents for shedding pounds, they are not a standalone solution and lasting health benefits relies on combined lifestyle changes.
